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Ozempic Tongue? How the Drug Can Change Some Women’s Ability to Taste

Did you know that people who struggle with obesity often find that their sense of taste isn’t as sharp as it could be? Well, there’s recent research that has some intriguing news. It turns out that Ozempic (which treats diabetes and aids in weight loss) might just have a bonus feature—it can actually enhance taste sensitivity in women dealing with obesity.

In a recent study, researchers discovered that this drug doesn’t just work superficially; it goes deep, changing gene expression in the tongue, which is crucial for how we perceive tastes. Those who participated in the study found their ability to taste sweets improved and noticed changes in how their brains react to these flavors.

How Does Ozempic (Semaglutide) Enhance Taste?

We all know that food can taste sweet, sour, salty, bitter, or even umami, a savory flavor. But have you noticed that not everyone experiences these tastes in the same way? Some might be particularly sensitive to sweetness, while others might find sour tastes more pronounced. It’s also interesting that the way food smells can affect how it tastes. But here’s the kicker—certain factors like smoking, getting older, using particular medications, and even obesity can change our taste over time. Previously, scientists found that people with obesity might have fewer taste buds, which can dull their sense of taste.

This brings us to fascinating research from the University of Ljubljana in Slovenia. They’ve been studying drugs containing semaglutide, which you might know as the active ingredient in medications like Wegovy and Ozempic. What they found is pretty exciting—this drug can boost taste sensitivity in obese women.

Here’s what’s happening: semaglutide (Basically Ozempic pen use) seems to tweak gene expression in the tongue, specifically the genes that help us taste. It also alters how the brain responds to sweet flavors. This could mean that foods might taste differently, perhaps better, to those who take the drug. The researchers shared these findings on June 1 at ENDO 2024, a big event hosted by the Endocrine Society in Boston, MA. Remember that this research is still hot off the press and hasn’t been published in a peer-reviewed journal yet. Dr. Mojca Jensterle Sever, who led the study, shared these insights with the medical community, sparking a lot of interest in how this could help people experiencing taste changes due to obesity.

Connection Between GLP-1 Drugs, Taste Sensitivity, Obesity

In the study, the researchers recruited 30 women with an average BMI of 36.4. Over a period of 16 weeks, they were given either the drug Ozempic, Wegovy (semaglutide), or a placebo, which is basically a treatment with no therapeutic effect. Dr. Mojca Jensterle Sever, who spearheaded the research, explained that they thoroughly chose who participated. They wanted to ensure other factors influencing taste, like age, diabetes, or smoking, didn’t interfere with the results. So, they picked a group of women who were quite similar in their health conditions—none had serious chronic diseases or lifestyle habits that could skew the taste tests. They even selected women with polycystic ovary syndrome who don’t ovulate to keep things consistent throughout different menstrual phases.

During these 16 weeks, the team used a unique method to measure the participants’ sensitivity to different tastes. They used strips that had varying concentrations of the four basic tastes. The idea was to discover the smallest amount of taste these women could detect before and after treatment. Interestingly, they didn’t focus on whether improving taste sensitivity led to weight loss; that wasn’t part of this study. Instead, they used MRI scans to see how the participants’ brains reacted to sweet tastes before and after they ate a standard meal. They also took a small tissue sample from each woman’s tongue to look at mRNA expression, which tells us about taste-related gene activity.

Changes to Taste Perception with Ozempic Use

Participants who took semaglutide drugs didn’t just experience a change in how they tasted foods; there were also noticeable changes at a genetic level in their taste buds and in how their brains reacted to sweet flavors. Dr. Mojca Jensterle Sever highlighted that this isn’t the first time how Ozempic works have been observed to alter food preferences. Research has shown that people treated with this drug often find their cravings for sweet, savory, and salty foods diminished.

However, Dr. Sever quickly pointed out that this study was very specific—focused only on one type of taste in a controlled setting, which might not fully capture how we experience tastes in our everyday lives. Taste is a personal thing and varies widely from one person to another, making it challenging to say how broadly these results apply to everyone.

She also mentioned some technical aspects of the research, like the limitations of mRNA sequencing used in their study. While this method tells us a lot about gene expression, it doesn’t directly show changes in protein levels or their activity, which are crucial for understanding the full picture. Looking ahead, Dr. Sever is optimistic. 

Does Ozempic & Wegovy Affect Weight Loss, or Is It Taste?

After reviewing the research on semaglutide’s impact on taste sensitivity, Dr. Mir Ali, a bariatric surgeon and the medical director at MemorialCare Surgical Weight Loss Center in California, found the results quite thought-provoking. He noted that changes in taste aren’t uncommon in patients who have undergone weight loss surgery, so the findings weren’t entirely unexpected. However, Dr. Ali raised a crucial question: Is it the semaglutide in the drug itself altering taste, or is it the weight loss that changes how flavors are perceived?

Can Improving Our Sense of Taste Help in Weight Loss?

According to Dr. Mojca Jensterle Sever, the answer might be yes. She sees taste as a crucial “gatekeeper” in our eating habits. When we enjoy rich, calorie-heavy foods too often, it can lead to obesity and diabetes. But if we can enhance how we taste, we might be able to control our cravings and food intake better.

Dr. Sever explains that taste does more than just let us enjoy our meals—it plays a key role in how we perceive the quality and pleasure of foods. Here’s how it works: the taste buds on our tongue pick up flavors and send these signals through nerves to our brain. The brain then sorts these flavors and determines their appeal, or what scientists call their “hedonic value.” This process helps the brain decide the reward value of food, which can influence how much we eat. Additionally, to buy Ozempic online Canada can help you ensure that you’ll receive genuine medications and not counterfeit ones.


The study on Ozempic offers a fascinating glimpse into how enhancing taste sensitivity might influence weight management. By potentially reshaping our experience of food flavors, this drug could alter eating behaviors and aid in the battle against obesity. This research underlines the complexity of taste and its impact on dietary choices, paving the way for innovative approaches to weight loss. As we unravel the intricate connections between taste perception and weight management, the potential for these insights to shape future treatments is immense, offering hope for more effective strategies in combating obesity.

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